Then there is the pig. Yuk joined a team at the Mayo Clinic that is more capable of performing operations on large animals. The team hopes to avoid relying on the natural clotting ability of blood, because many people undergoing surgery have blood clotting problems themselves. Therefore, before any experiment, all three test pigs received heparin, a blood thinner. The researchers cut three holes 1 cm wide and 1 cm deep in the liver of each animal, and then treated nine wounds with a paste or TachoSil patch.
One of the team’s veterinarians, Tiffany Sarrafian, said that she had never seen anything as effective as this glue. “We are just applying the paste, we are counting” for a few seconds, Sarrafian recalled the process. “You take your hand away and you are like,’Hold on, there is no blood!’ It’s amazing.”
Sarrafian originally planned that if the comparison commercial patch did not work after three minutes, she would reverse the anticoagulant to keep the pigs alive, and then let them coagulate and heal naturally. But she added another step to stop the bleeding faster: squeeze the pea-sized experimental glue with a plop. “In a sense, it’s kind of magical,” she said.
To be fair, coagulation patches like TachoSil are not meant to stop the massive blood flow from tissues that cannot be coagulated and damaged. But in the medical field, this is an unmet need, said Christoph Nabzdiq, a surgeon on the Mayo team. “As the population ages, more and more patients either suffer from bleeding disorders or end up using blood thinners,” he said. “Bleeding problems and bleeding control problems are serious.”
He and Salafian added that there is a cheap glue that can stop the bleeding with Surgery on an already damp surface may save the patient’s life, and it is especially useful in places where there are no large surgical resources (such as wilderness areas, war zones, or underdeveloped countries).
“Nothing in the material is new, but the concept is really cool and unconventional,” said Shrike Zhang, a biomedical engineer who leads the Harvard Medical School laboratory.Although materials such as silicone oil and adhesive components are common, their combination Exciting. “It’s too early, but the animal data is very powerful,” he continued.
However, Stanford Cardiothoracic Surgery Resident Wang said that there are still some factors that need to be optimized before the adhesive can be applied to the human body. A blob of glue that seals damaged tissue or sticks to surrounding healthy tissue in an emergency situation may complicate any subsequent surgery. “The question is, can you move in that area?” he asked.
Yuk’s team devised a solution to reverse this type of viscous seal, and initially Results in rats Very hopeful.
They also want to know how long this seal can last; ideally, it should not dissolve after the tissue has healed on its own, but it should not last forever. Based on microscope images from a separate experiment with rats, new research shows that the paste dissolves significantly within 12 weeks. Depending on the injury and healing response, this could be a lot.
Another challenge is that other types of sealants are known to kill tissue over time. Wang and Yuk pointed out that long-term research is crucial. So far, their longest observation of bleeding organs was about a month after applying the glue, using pigs tested at the Mayo Clinic.
Although it may take many years for sealants to replace reliable sutures, surgeons and mechanical engineers hope to bond patients together quickly and let the body function like a well-lubricated machine again.
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